オリゴオキシエチレンアルキネスのパラ水素化による13C-MRI用の新しい高極化コントラスト剤

Francesca Reineri¹, Alessandra Viale, Giovanbattista Giovenzana

¹Dipartimento di Chimica IFM, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.

Journal of the American Chemical Society

|October 17, 2008

まとめ

2つの新しいアルキン誘導体は,パラヒドロゲン化のための有効な基板であり,超極化アルケンを生成します. その結果得られた対称派生体は水溶性であり,in vivo MRIアプリケーションを可能にします.

科学分野:

ハイパーポラライズされたMRIコントラスト剤
有機合成による有機合成です.
量子化学は量子化学である

背景:

パラヒドロジネーションは,高極化化合物を生成する方法である.
ハイパーポラライズされた分子はMRIの感度を高めます.
アルキン基板は,新しい高極化剤を生成する可能性のために調査されています.

研究の目的:

パラヒドロゲネーションのための基質としてアルキン誘導体を合成し,評価する.
パラヒドロジネーションメカニズムを説明する理論的枠組みを開発する.
合成されたハイパーポラライズされた化合物がMRIアプリケーションに適しているかどうかを評価する.

主な方法:

オリゴオキシエチレン鎖によるアルキン誘導体の合成.
ALTADENAとPASADENAのテクニックを用いたパラヒドロジネーション反応.
パラ水素誘導効果の理論モデリング.
異なる溶剤でC-MRイメージングをインビトロ (13) で行う.
シグナル獲得の強化のためのフィールドサイクリング.

主要な成果:

2つのアルキン誘導体は,パラヒドロゲン化において良好な基板性能を示した.
対応するハイパーポラライズされたアルケンの高収量が得られた.
対称性および非対称性アルキンのパラヒドロゲン化効果を説明するための理論が開発されました.
シンメトリックな水素化された製品は,水溶性の良さを示した.
水溶液でC-MRイメージングを成功裏に in vitro (13) で実施した.

結論:

オリゴオキシエチレン鎖は,パラヒドロゲン化されたアルキン誘導体に水溶性を与えます.
水溶性製品は,分離と in vivo MRI の準備を容易にする.
これらの発見は,医療イメージングのための新しいハイパーポラライズされたコントラスト剤の開発をサポートしています.

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