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関連する概念動画

DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:16

The DNA Helix

Overview
Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...

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関連する実験動画

Updated: Jun 28, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

ダブルヘリクスの再測定

Rebecca S Mathew-Fenn1, Rhiju Das, Pehr A B Harbury

  • 1Biophysics Program, Stanford University, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|October 18, 2008
PubMed
まとめ
この要約は機械生成です。

DNAはこれまで考えられていたよりも柔らかく,短距離で弾性棒モデルに挑戦しています. これは,DNA構造内の協同的な伸縮と長距離通信を示唆しています.

さらに関連する動画

Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution
10:27

Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution

Published on: July 8, 2019

Single-Molecule Real-Time Visualization of DNA Unwinding by CMG Helicase
07:37

Single-Molecule Real-Time Visualization of DNA Unwinding by CMG Helicase

Published on: September 27, 2024

関連する実験動画

Last Updated: Jun 28, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution
10:27

Dual DNA Rulers to Study the Mechanism of Ribosome Translocation with Single-Nucleotide Resolution

Published on: July 8, 2019

Single-Molecule Real-Time Visualization of DNA Unwinding by CMG Helicase
07:37

Single-Molecule Real-Time Visualization of DNA Unwinding by CMG Helicase

Published on: September 27, 2024

科学分野:

  • 分子生物学は分子生物学である.
  • バイオフィジックス 生物物理学
  • 構造生物学 構造生物学とは

背景:

  • DNAは,その機械的振る舞いを理解するために,硬い弾性棒としてモデル化されることが多い.
  • 普遍的な機械的変形は,DNAの生物学的機能に固有のものです.
  • 以前の研究では,主に単一分子ストレッチ実験を使用しました.

研究 の 目的:

  • 短いDNAの長さの機械的性質を調査するために.
  • DNAに対する従来の弾性棒モデルの有効性をテストするために.
  • DNAの長さと端から端までの長さの差異の関係を決定する.

主な方法:

  • 小角X線散射 (SAXS) 干渉を利用した.
  • DNAのダブルヘリクに付着したゴールドナノクリスタルラベルを使用した.
  • 溶液中のDNAの端から端までの長さの測定された平均値と変数.

主要な成果:

  • DNAは,単一分子ストレッチ実験で予測されるよりも,少なくとも1次元の柔らかくなります.
  • DNAの従来型の弾性棒モデルは,データによって支持されていません.
  • エンドツーエンドの長さのバリエーションは,線形ではなく二次的であり,ベースペアの数に依存していることを示しています.

結論:

  • 短いDNAセグメントは,以前にモデル化されたものとは著しく異なる機械的性質を示しています.
  • DNAのストレッチは,2つ以上の螺旋回転に及ぶ協力的なプロセスです.
  • 発見は,DNA構造によって媒介される長距離アロステル通信の概念を裏付けている.