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Updated: Jun 28, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

スピロベータラクトンプロテアソーム阻害剤の構造分析

Michael Groll1, Emily P Balskus, Eric N Jacobsen

  • 1Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.

Journal of the American Chemical Society
|October 22, 2008
PubMed
まとめ

研究者らは (+) - ラクタシスティンにインスパイアされた新しいスパイロベータ-ラクトンプロテアソーム阻害剤を開発しました. ある化合物は26Sプロテアソームを強力に阻害し,そのエピマーは弱い活性を示し,薬物設計に関する洞察を提供した.

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Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

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