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Updated: Jun 28, 2026

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

53BP1は,V(D) J再結合の際に長距離のDNA末端結合を促進する

Simone Difilippantonio1, Eric Gapud, Nancy Wong

  • 1Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA.

Nature
|October 22, 2008
PubMed
まとめ

53BP1タンパク質は,リンパ球におけるV(D) J再結合中のDNA修復に不可欠です. 欠乏すると,コードの末端の劣化とゲノム不安定が起こり,T細胞の欠陥やリンパ減少を引き起こす.

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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
Homologous Recombination02:31

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