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Updated: Jun 28, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
10:59

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

Published on: May 13, 2019

トランスクリブするT7RNAポリメラーゼの構造は,イニシエーションから延長への移行段階にある

Kimberly J Durniak1, Scott Bailey, Thomas A Steitz

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA.

Science (New York, N.Y.)
|October 25, 2008
PubMed
まとめ

構造的研究により,T7細菌のDNA依存RNAポリメラーゼ (T7 RNAP) が,転写開始と延伸の間の移行をどのように行っているかが明らかになった. 中間結晶構造は,プロモーター結合ドメインの回転を示し,RNA合成に対応しながらDNA接触を維持します.

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Transcription Initiation01:47

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Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA into a...
Bacterial Transcription01:53

Bacterial Transcription

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Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

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Bacterial RNA Polymerase00:43

Bacterial RNA Polymerase

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