関連する実験動画

Updated: Jun 28, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

カリウムチャネルに対するスクリーニングブロッカーは,ドロップレットインターフェースバイレイヤー配列配列を持つ.

Ruhma Syeda1, Matthew A Holden, William L Hwang

  • 1Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

Journal of the American Chemical Society
|October 28, 2008
PubMed
まとめ

ドロップレットインターフェースの2層は,イオンチャネルのような膜タンパク質の自発的な挿入を可能にします. これにより,潜在的なチャネルブロッカーを迅速にスクリーニングするための新しいチップベースの方法が可能になります.

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Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

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関連する概念動画

Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...