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Updated: May 5, 2026

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

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RNAポリメラーゼ"スイッチ領域"は,阻害剤の標的である

Jayanta Mukhopadhyay1, Kalyan Das, Sajida Ismail

  • 1Howard Hughes Medical Institute, Rutgers University, Piscataway, NJ 08854, USA.

Cell
|October 30, 2008
PubMed
まとめ

ミキソピロニン抗生物質は,スイッチ領域を標的とし,DNA結合を防ぐことで,細菌のRNAポリメラーゼ (RNAP) を阻害する. このメカニズムは,広範囲の抗菌薬の開発に新たな道を開く.

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