関連する実験動画

Updated: Jun 23, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 3, 2010

サイトカイン誘発信号ネットワークは,信号の強度よりもダイナミックレンジを優先します

Kevin A Janes1, H Christian Reinhardt, Michael B Yaffe

  • 1Koch Institute for Integrative Cancer Research, Center for Cell Decision Processes, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|October 30, 2008
PubMed
まとめ

細胞の信号伝達経路は,信号の強度だけでなく,ダイナミックレンジを通じて情報を伝達します. このダイナミックレンジを理解することは,細胞アポトーシスを予測し,ネットワーク応答のシグナル伝達における壊滅的な障害を回避するために不可欠です.

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Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Intracellular Signaling Cascades01:24

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Interactions Between Signaling Pathways

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Amplifying Signals via Enzymatic Cascade

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