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Updated: Jun 28, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
10:51

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

大型のキナーゼ活性部位を,硬直で重量のある八面体ルテニウム複合体で標的にする

Jasna Maksimoska1, Li Feng, Klaus Harms

  • 1The Wistar Institute and University of Pennsylvania, Department of Chemistry, Philadelphia, Pennsylvania 19104, USA.

Journal of the American Chemical Society
|November 1, 2008
PubMed
まとめ

研究者らは,大規模なタンパク質キナーゼのATP結合部位を標的とした新しいルテニウム複合体を開発した. Lambda-FL172のような巨大な八面体化合物は,PAK1を効果的に阻害し,キナーゼ阻害剤の設計における新しい戦略を示しています.

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Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction10:39

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction

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