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Updated: Jun 28, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
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新しい小分子で,シェルテリンの整合性を変化させ,テロメアでDNA損傷反応を誘発する

Raphaël Rodriguez1, Sebastian Müller, Justin A Yeoman

  • 1The University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.

Journal of the American Chemical Society
|November 4, 2008
PubMed
まとめ

新しい小分子は,ヒトのテロメアG四重複DNAを選択的に安定させる. この化合物はテロメラーゼを阻害し,がん細胞におけるPOT1結合を阻害し,テロメアの変化を引き起こす.

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