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Updated: May 7, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

CD8トランスジェニックマウスの胸膜の選択は,CD4またはCD8系統へのコミットメントのための教育的なモデルをサポートしています

E A Robey1, B J Fowlkes, J W Gordon

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032.

Cell
|January 11, 1991
PubMed
まとめ

胸腺におけるポジティブ・セレクションは,CD8が早期に発現すると,CD8+T細胞の発達を改善する. これは,自己MHC認識がT細胞系統へのコミットメントを指示するモデルを示唆しています.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...