ドロソフィラガストルレーション遺伝子のコンサーチナは,Gアルファのようなタンパク質をコードする
1Department of Molecular Biology, Princeton University, New Jersey 08540.
Cell
|January 25, 1991
まとめ
Concertina (cta) 遺伝子は,ドロソフィラ菌の胃増殖に不可欠であり,胚の発達中の細胞形状の変化を調節する. 変異は腹腔の形成を妨害し,重要な細胞信号伝達経路におけるその役割を示している.
科学分野:
- 発達生物学 発達生物学とは
- 細胞生物学 細胞生物学
- 遺伝学 遺伝学とは
背景:
- 胃流は,細胞の形状の変化と動きの調整を伴う.
- ドロソフィラでは,胃化の始まりは,腹と中腸後部の形成である.
- アピカル収縮は,これらのインヴァギナーションの間に細胞の形状の変化を促します.
研究 の 目的:
- ドロソフィラ菌の胃増殖におけるコンサーチナ (cta) 遺伝子の役割を調査する.
- 胚の発達中の細胞の形状の変化の基礎となる分子機構を理解する.
主な方法:
- コンサーチナ (cta) 遺伝子のホモジゴス変異を有するドロソフィラ胚の分析.
- 細胞形態学との形成の検査.
- 遺伝子クローニングとcta遺伝子の配列分析.
主要な成果:
- 機能的なCTAが欠けている胚は,組織化された腹を形成することができません.
- 毛穴形成の初期段階が起こりますが,その後の細胞収縮は不十分です.
- 配列解析は,ctaがGタンパク質アルファサブユニットをコードすることを示唆しています.
結論:
- 協奏曲 (cta) 遺伝子は,ドロソフィラ菌の gastrulation 中の適切な細胞収縮のために不可欠です.
- ctaは,細胞間の通信を媒介する信号伝達経路内で機能する可能性が高い.
- Gタンパク質のシグナル伝達は,胚の発達における細胞の動きの調整に不可欠です.
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