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Updated: Jun 23, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Published on: July 17, 2019

GAP結合/"エフェクタ"ドメインの変異によるRasHの腫瘍性形態の優先抑制

C L Farnsworth1, M S Marshall, J B Gibbs

  • 1Department of Biochemistry, Tufts University Health Sciences Campus, Boston, Massachusetts 02111.

Cell
|February 8, 1991
PubMed
まとめ

RasHタンパク質の突然変異は,正常なRash機能を保ちながら,腫瘍的形態を選択的に減少させます. これは,Rasタンパク質のエフェクタドメインを阻害することによって,Ras駆動がんに対する標的治療戦略を示唆しています.

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