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Updated: Jun 28, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
06:50

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

タンパク質の二極化は,PPAR-gammaへのリガンド結合におけるAF-2とhelix-2'ドメインの安定化に不可欠である

C G Ji1, J Z H Zhang

  • 1Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

Journal of the American Chemical Society
|November 15, 2008
PubMed
まとめ

タンパク質の二極化は,ペロキシソーム増殖器活性化受容体 (PPAR-gamma) の安定化と,ロシグリタゾンなどのアゴニストとの結合に不可欠です. この研究は,二極化が生物学的機能にとって不可欠な水素結合とタンパク質構造をどのように保存するかを強調しています.

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