固有の白血球-内皮粘着阻害剤であるデル-1は,炎症細胞の募集を制限する
Eun Young Choi1, Emmanouil Chavakis, Marcus A Czabanka
1Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Science (New York, N.Y.)
|November 15, 2008
まとめ
発達内皮位-1 (Del-1) は,白血球の粘着を阻害する,新たに特定された分子です. マウスのデル-1欠乏症は炎症性細胞の募集を増加させ,免疫応答の調節におけるその役割を示唆する.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
- 分子生物学は分子生物学である.
背景:
- 白血球の徴募は,感染や炎症の部位での免疫反応にとって極めて重要です.
- 白血球粘着を促進する多くの分子が知られているが,内生性阻害剤はほとんど特徴づけられていない.
研究 の 目的:
- 白血球粘着の内生性阻害剤を特定し,特徴づけること.
- 白血球-内皮相互作用における内皮由来の分子Del-1の役割を調査する.
主な方法:
- 白血球-内皮粘着を評価するためのインビトロおよびインビボアッセイ.
- マウスにおけるDel-1とLFA-1の遺伝子操作 (Del-1-/-, Del-1/LFA-1二重欠乏症).
- リポポリサッカリド誘発肺炎モデルにおける中性粒子の蓄積の評価.
主要な成果:
- Del-1は抗粘着因子として作用し,インテグリンLFA-1-依存型白血球-内皮粘着を阻害する.
- 内皮の Del-1 欠乏症は,白血球の粘着を in vitro と in vivo で増加させた.
- Del-1ノックアウトマウスは,肺炎中に中性粒子の蓄積が増加し,これは二重欠乏マウスでは廃止されました.
結論:
- Del-1は,炎症性細胞募集の内生性阻害剤である.
- Del-1は白血球と内皮細胞の相互作用を調節する上で重要な役割を果たします.
- Del-1をターゲットにすることは,炎症性疾患の治療戦略を提供することができる.
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