Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

3.0K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
3.0K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetes.

bioRxiv : the preprint server for biology·2026
Same author

Cross-presentation of citrullinated antigens drives cytotoxic CD8 <sup>+</sup> T cell responses in rheumatoid arthritis.

bioRxiv : the preprint server for biology·2026
Same author

Human vaccine responses regulated by parallel cytokine pathways.

Nature immunology·2026
Same author

Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.

JCI insight·2026
Same author

Immune Aging is an Independent Risk Factor for Cardiovascular Disease.

bioRxiv : the preprint server for biology·2026
Same author

Aging restricts maturation of CXCL13<sup>+</sup> T follicular helper cells in human immunity.

Cell reports·2026

関連する実験動画

Updated: Apr 30, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

25.3K

TCRトリガーの安全性について

Michael S Kuhns1, Mark M Davis

  • 1Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|November 18, 2008
PubMed
まとめ

研究者らは,新しいT細胞受容体 (TCR) 調節機構を発見した. TCR 細胞質ドメインの基本残留物は,T細胞活性化前に信号発信チロシンを隔離して,血に結合する.

科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.

背景:

  • T細胞受容体 (TCR) は,抗原認識時にT細胞の活性化を開始し,適応性免疫にとって極めて重要です.
  • TCRの調節を理解することは,免疫反応の制御と免疫療法の開発の鍵です.

研究 の 目的:

  • 活性化前にT細胞受容体調節の新しいメカニズムを解明する.

主な方法:

  • この研究では,タンパク質と膜の相互作用を調査するための生化学的および生体物理的技術が関与した可能性が高い.
  • 細胞プラズマ領域とプラズマ膜の相互作用の分析.

主要な成果:

  • 新しいT細胞受容体調節機構の証拠が提供されました.
  • TCRサイトプラズマドメインの基本残留物は,活性化前にプラズマ膜と結合する.
  • 鍵となるシグナル伝達チロシンは,プラズマ膜の二重層の中に隔離されている.

結論:

  • この発見は,これまで知られていなかったTCR規制の仕組みを明らかにしています.
  • TCRのプリアクティベーション状態は,シグナリングモチーフを隔離することによって維持されます.

さらに関連する動画

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
08:46

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

53.3K
Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation
08:24

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Published on: August 16, 2021

6.3K

関連する実験動画

Last Updated: Apr 30, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

25.3K
A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
08:46

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

53.3K
Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation
08:24

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Published on: August 16, 2021

6.3K