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Updated: Aug 15, 2026

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Nitropeptide Profiling and Identification Illustrated by Angiotensin II
Published on: June 16, 2019
アンジオテンション変換酵素阻害剤による窒素耐性の予防
1Department of Medicine, George Washington University, Washington, DC 20037.
Circulation
|April 1, 1991
まとめ
エナラプリルやキャプトプリルなどのアニオテンシン変換酵素 (ACE) 阻害剤は,ニトログリセリン耐性を防ぐ可能性があります. この研究では,ACE阻害剤が74時間の連続使用後にプラセボと比較して,ニトログリセリンの耐性を著しく低下させたことが判明しました.
科学分野:
- 心血管薬理学について
- 薬理学 薬理学とは
- 臨床薬理学 臨床薬理学とは
背景:
- ニトログリセリンの耐性は,神経性ホルモンの活性化または硫黄水素の枯渇を含む可能性があります.
- アンジオテンシン変換酵素 (ACE) 阻害剤は,窒素耐性を防ぐ可能性について調査されました.
研究 の 目的:
- ニトログリセリンとACE阻害剤 (エナラプリル,カプトプリル) の相互作用を評価するために,硫黄水素基を併用してまたは併用せずに.
- 長期にわたる窒素酸塩療法中にACE阻害剤がニトログリセリン耐性の発症を予防できるかどうかを判断する.
主な方法:
- 34人の被験者は,エナラプリル,カプトプリル,またはプラセボを7日間投与された.
- サブリンガル・ニトログリセリンに対する静脈拡張剤の反応は,前腕プレチスモグラフィを用いて測定された.
- 測定は,ベースラインで,4日後に,2時間および74時間の連続したニトログリセリンパッチの適用後に行われました.
主要な成果:
- ACE阻害だけでは,言語下ニトログリセリンの反応は変化しませんでした.
- ニトロパッチの使用から2時間後,すべてのグループでニトロ酸性反応は変化しませんでした.
- 74時間後,ニトログリセリンに対する静脈拡張剤の反応は,プラセボ群では40%,エナラプリル群では10%,キャプトプリル群では2%減少した.
- ACE阻害剤は,酸塩耐性および酸塩誘発の体積膨張を有意に防止しました.
結論:
- アンジオテンシン変換酵素 (ACE) 阻害剤は,窒素耐性を予防する可能性があることを示しています.
- 長期にわたるニートレート療法は,ACE阻害剤と併用すると,より効果的になる可能性があります.
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