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PA-824は,細胞内 NO の放出によって,複製しない Mycobacterium tuberculosis を殺します

Ramandeep Singh1, Ujjini Manjunatha, Helena I M Boshoff

  • 1Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|November 29, 2008
PubMed
まとめ

PA-824のようなバイサイクルニトロイミダゾールは,Rv3547によって活性化され,デス-ニトロ代謝産物となる. これらの代謝産物は窒素酸化物 (NO) を生成し,これはMycobacterium tuberculosisを無酸素で殺すのに不可欠です.

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