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タンパク質キナーゼRは,ウイルスのミミクリを倒すための進化モデルを明らかにしています

Nels C Elde1, Stephanie J Child, Adam P Geballe

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

Nature
|December 2, 2008
PubMed
まとめ

タンパク質キナーゼR (PKR) のような宿主タンパク質は,病原体模倣を克服するために進化します. 霊長類におけるポジティブ・セレクションを含む進化戦略により,PKRは,その認識部位を適応させることで,ウイルスの模倣を回避することができます.

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