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Updated: May 6, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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DNA上の無傷のPPAR-gamma-RXR-核受容体複合体の構造

Vikas Chandra1, Pengxiang Huang, Yoshitomo Hamuro

  • 1Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908-0735, USA.

Nature
|December 2, 2008
PubMed
まとめ

この研究では,無傷のペロキシソーム増殖器活性化受容体-ガンマ (PPAR-ガンマ) とレチノイドX受容体-アルファ (RXR-アルファ) の異体体がDNAとリンガンドを結合する方法が明らかにされています. PPAR-ガンマリンガンド結合ドメインは,遺伝子調節を強化するためにDNA結合ドメインと協力します.

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