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Updated: Jun 27, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
07:07

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology

Published on: March 12, 2015

オーガノセレニウム媒介の分子内ヒドロキシエテリフィケーションによる (-) - ローレフシンのバイオミテック非対称的全合成

Byungsook Kim1, Miseon Lee, Mi Jung Kim

  • 1The Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

Journal of the American Chemical Society
|December 4, 2008
PubMed
まとめ

研究者らは,C-15アセトゲニンである (-) - ローレフシンの最初の非対称的全合成を達成しました. このバイオミテック・ヒドロキシエテリフィケーションは,合成有機化学における重要な進歩である.

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Alkenes can be obtained from amines via an E2 elimination. The amine is first converted into a good leaving group, such as a quaternary ammonium salt. This is accomplished by treating the amine with an excess of alkyl halide, which results in a halide salt. Next, the halide salt is transformed into a hydroxide salt that functions as a base to enable elimination.
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