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Updated: Jun 27, 2026

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GDP-フコース合成酵素のメカニズムと活性部位残留物

Stephen T B Lau1, Martin E Tanner

  • 1Department of Chemistry, University of British Columbia, Vancouver, British Columbia, V6T 1Z1 Canada.

Journal of the American Chemical Society
|December 5, 2008
PubMed
まとめ

この研究では,GDP-L-fucose.を生産するGDP-フコゼ合成酵素 (GFS) の段階的なメカニズムが明らかにされています. 主要な残留物Cys109とHis179は,エピメリゼーションのステップにおける重要な酸/塩基触媒として特定されています.

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