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Updated: Jun 27, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

新しいテトラサイクリン抗生物質の合成のための堅牢なプラットフォームです

Cuixiang Sun1, Qiu Wang, Jason D Brubaker

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|December 5, 2008
PubMed
まとめ

新しいコンバージェント合成により,多様なテトラサイクリンおよび同類剤の作成が可能になります. マイケル・クレイゼン濃縮を用いたこの方法は,高いステレオ化学制御を持つ強力な新型抗生物質を生成し,従来の半合成アプローチの代替案を提供します.

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