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Updated: Jun 27, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

競争力のある阻害剤は,LEUTをオープン・トゥ・アウト・コンフォーメーションに閉じ込めます

Satinder K Singh1, Chayne L Piscitelli, Atsuko Yamashita

  • 1Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.

Science (New York, N.Y.)
|December 17, 2008
PubMed
まとめ

セカンダリートランスポーターは,分子を膜に移動させます. レウシントランスポーター (LeuT) に関する研究では,基板がどのように構造変化を引き起こし,トリプトファン (Trp) のような阻害剤がトランスポーターを開いた状態に閉じ込めて輸送をブロックするかを明らかにしています.

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Comparing the Affinity of GTPase-binding Proteins using Competition Assays10:37

Comparing the Affinity of GTPase-binding Proteins using Competition Assays

Published on: October 8, 2015

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

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