接触 移動の抑制 in vivo コントロール 神経頂部 方向的移住
Carlos Carmona-Fontaine1, Helen K Matthews, Sei Kuriyama
1Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK.
Nature
|December 17, 2008
まとめ
移動の接触阻害は,細胞の行動であり,神経の細胞では,体内および体外の両方で観察されました. 非正規のWnt信号によって制御されるこの現象は,方向性細胞移動を説明し,侵入を防ぐ.
科学分野:
- 発達生物学 発達生物学について
- 細胞生物学 細胞生物学
- がん生物学 がん生物学
背景:
- 移動の接触阻害 (CIL) は,細胞が接触時に停止し,方向を変更する方法を説明します.
- CILの機能不全は悪性侵襲と関連しているが,そのin vivo発生と分子基盤は不明である.
研究 の 目的:
- 神経頂部細胞におけるCILのインビボ発生と分子メカニズムを調査する.
- 方向性細胞移動と組織侵入におけるCILの役割を決定する.
主な方法:
- ニューラル・クライスト細胞の移動の生画像 in vivo および in vitro.
- 非正規のWnt信号伝達経路の混乱.
- 細胞と細胞の接触ダイナミクスと突起の収縮の分析.
主要な成果:
- 神経頂部細胞は,CILを in vivo および in vitro で表し,突起を撤回し,接触時に方向を変更します.
- CILはニューラル・クライストの細胞-細胞の相互作用に特異的であり,他の細胞タイプを侵略します.
- 非正規のWnt信号の阻害は,CILと方向移動を妨害する.
結論:
- この研究は,CIL.の最初のin vivo証拠を提供します.
- 神経頂層細胞のCILは,非正規のWntシグナル伝達と接触部位でのRhoA活性化によって媒介されます.
- CILは,一貫した集団の移住について説明し,侵入を防ぐためにWntシグナリングの新たな役割を強調しています.
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