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転写因子サイクルAMP応答要素調節器の重要な役割は,β1-アドレノ受容体媒介の心臓機能不全におけるものです

Geertje Lewin1, Marek Matus, Abhijit Basu

  • 1Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany.

Circulation
|December 24, 2008
PubMed
まとめ

循環型AMP応答要素調節器 (CREM) は,鍵となる心臓遺伝子を改変することによって,ベータ(1) - アドレノ受容体誘発性心不全を引き起こします. CREMを阻害すると,マウスモデルでの心臓損傷と機能不全から保護されます.

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