出生体重と2型糖尿病のリスク:体系的なレビュー
Peter H Whincup1, Samantha J Kaye, Christopher G Owen
1Division of Community Health Sciences, St George's, University of London, Cranmer Terrace, London SW17 0RE, England. p.whincup@sgul.ac.uk
JAMA
|December 26, 2008
まとめ
低出生体重は,成人における2型糖尿病のリスク低下と関連しています. この逆相関は,出生時に体重が3kg以下であった個体では特に顕著である.
科学分野:
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
- メタボリック疾患
背景:
- 低出生体重は,2型糖尿病の危険因子であると疑われています.
- これまでの研究は,この関連の強さ,一貫性,独立性,形状を体系的に評価していませんでした.
研究 の 目的:
- 成人の出生体重と2型糖尿病との関連に関する公表された証拠の定量的な体系的なレビューを実施する.
主な方法:
- EMBASE,MEDLINE,Web of Scienceで,2008年6月までに発表された関連の研究を検索しました.
- 出生体重と2型糖尿病との関連を定量的にまたは質的に推定した研究が含まれています.
- ランダム効果モデルを使用して,コバリアートに調整し,特定の集団を除外したプールの推定値.
主要な成果:
- 31件の関連レポート (31人の集団,6090人の糖尿病患者,152,084人の個人) を分析した.
- ほとんどの集団で出生体重と2型糖尿病リスクの逆相関が見られた (合計OR 0.75 per kg).
- この関連性は,特に出生体重 ≤3kgの場合,分類され,BMIを調整した後に強化されました.
結論:
- 出産時の体重は,研究された大部分の集団における2型糖尿病のリスクと逆関係にある.
- この発見は,成人2型糖尿病リスクの決定因子としての出生体重の重要性を強調しています.
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