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Bacterial Phylum Spirochaetes
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DDB1-DDB2複合体によるUVDNA損傷認識の構造的基礎

Andrea Scrima1, Renata Konícková, Bryan K Czyzewski

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland.

Cell
|December 27, 2008
PubMed
まとめ

DDB1-DDB2複合体は,ユニークな構造機構を使用して,UVのDNA損傷を検出します. このプロセスは,DDB2ヘアピンを使用して,光傷を正確に探査し,結合させ,難しいDNA病変の検出を可能にします.

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