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Updated: Jun 26, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
10:01

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach

Published on: June 23, 2026

サイクロフィリンAにおける移行状態安定化の役割に関するメカニズム的洞察

Donald Hamelberg1, J Andrew McCammon

  • 1Department of Chemistry, Georgia State University, Atlanta, Georgia 30302-4098, USA.

Journal of the American Chemical Society
|January 9, 2009
PubMed
まとめ

ペプチジルプロリルシストランスイソメラーゼ (PPIases) は,重要なタンパク質構成の変化を触媒化する. 分子ダイナミクスシミュレーションでは,サイクロフィリンAが水素結合を通じて移行状態を安定させ,触媒作用を強めることが示されています.

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X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep105011:27

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