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HIV-1プロテアゼの選択された突然変異により,フラップの形状が変化します

Luis Galiano1, Fangyu Ding, Angelo M Veloro

  • 1Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, Florida 32611, USA.

Journal of the American Chemical Society
|January 15, 2009
PubMed
まとめ

薬剤耐性HIV-1プロテアゼは,突然変異により,フラップの柔軟性と形状が変化している. これらの変化は,HIV-1プロテアスが抗ウイルス薬に対する耐性をどのように開発するかについての構造的洞察を提供します.

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