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関連する概念動画

Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Multi-pass Transmembrane Proteins and β-barrels01:09

Multi-pass Transmembrane Proteins and β-barrels

In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as G-protein-linked receptors (GPCRs) and...
What are Membranes?01:54

What are Membranes?

A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and Golgi...

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関連する実験動画

Updated: Jun 26, 2026

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties
12:20

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties

Published on: November 3, 2008

結合ポリマーの構造変化に対する生物膜の感受性

Alexander A Yaroslavov1, Tatiana A Sitnikova, Anna A Rakhnyanskaya

  • 1Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory, Moscow, RF.

Journal of the American Chemical Society
|January 20, 2009
PubMed
まとめ
この要約は機械生成です。

ズウィートリオン系ポリマーはアニオン系リポソームと相互作用し,脂質の再編成を引き起こします. ポリマースペーサーの長さは,リポソーム製剤における結合,吸収,脂質分離,およびフリップフロップ効果を決定する.

さらに関連する動画

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

関連する実験動画

Last Updated: Jun 26, 2026

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties
12:20

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties

Published on: November 3, 2008

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

科学分野:

  • バイオケミストリー バイオケミストリー
  • マテリアルサイエンス 材料科学
  • ナノテクノロジー ナノテクノロジー

背景:

  • アニオン性リポソームは,薬物投与システムにおいて極めて重要です.
  • ポリエレクトロライトは,バイオメディカル製剤で広く使用されています.
  • ポリエレクトロライト-リポソームの相互作用を理解することは,配方安定性と有効性の鍵です.

研究 の 目的:

  • アニオン性リポソームとズウィテリオン性ポリマーの相互作用を調査する.
  • ポリマースペーサーの長さがリポソームの構造とダイナミクスに与える影響を決定する.
  • リポソームにおけるポリエレクトロライト誘発の分子再配置のメカニズムを解明する.

主な方法:

  • 特定のフォスフォリピド比率を持つアニオン性リポソームの調製.
  • リポソームの処理は,スペーサーの長さが異なる5つのズウィテリオンポリマーで行われます.
  • リポソームの完全性,吸収,脂質分離,フリップフロップ現象の分析.

主要な成果:

  • ポリマーはリポソームの構造的完全性を破壊しませんでした.
  • スパッサーの長さは,ポリマー結合とリポソーム応答を決定した.
  • スパッサーの長さ1と2では,結合/再配置が全くないか,ごくわずかであった.
  • スパッサーの長さ3,4,5で誘発された横の脂質分離とフリップフロップ効果.

結論:

  • Zwitterionicポリマースペーサーの長さは,リポソームの行動を調節する重要な要因です.
  • スパッサー依存の相互作用は,分離とフリップフロップを含む制御された脂質の再編成につながる可能性があります.
  • 発見は,ポリエレクトロライト-リポソームシステムを利用した先進的な生物医学製剤の設計に関連しています.