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Updated: Jun 26, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

アイソ・ドゥオカルミシンSAとアイソ・ヤタケミシンSAの総合合成と評価

Karen S MacMillan1, Trinh Nguyen, Trihn Nguyen

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 22, 2009
PubMed
まとめ

研究者らは,変異したアルキル化サブユニットを持つ新しいドゥオカルミシンアナログ,イソ-ドゥオカルミシンSAおよびイソ-ヤタケミシンを合成した. これらの化合物は強力なDNAアルキル化と細胞毒性を示し,天然製品の薬物設計に関する洞察を提供します.

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