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一般的な不安障害を持つ高齢者のためのエスキタロプラム:ランダム化制御試験
Eric J Lenze1, Bruce L Rollman, M Katherine Shear
1Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA. lenzee@wustl.edu
JAMA
|January 22, 2009
まとめ
エシタロプラムなどのセロトニン再吸収抑制剤 (SSRI) は,高齢者の全般的な不安障害 (GAD) を改善する可能性があります. しかし,この集団における長期的な有効性と安全性を確認するためにさらなる研究が必要である.
科学分野:
- 高齢者精神科医の精神医学について
- 臨床薬理学 臨床薬理学とは
- 精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは,精神薬理学 (Psychopharmacology) とは
背景:
- 一般的な不安障害 (GAD) は,高齢者の間で多く見られるが,治療ガイドラインは限られている.
- 選択的セロトニン再吸収阻害剤 (SSRI) は,若い成人のGADに対して有効ですが,高齢者の集団におけるその有効性と安全性は,特定の調査を必要とします.
研究 の 目的:
- 60歳以上の成人の全般性不安障害 (GAD) の治療におけるエシタロプラムの有効性,安全性,耐受性を評価する.
- 高齢GAD患者における不安症状と機能的アウトカムに対するエシタロプラムの効果とプラセボの効果を比較する.
主な方法:
- GADと診断された177人の参加者 (年齢60歳以上) を含む12週間のランダム化プラセボ対照試験.
- 参加者はエシタロプラム (10〜20mg/日) またはマッチングしたプラセボを投与された.
- 結果には,累積的な応答率,応答までの時間,不安症状の重症度 (ハミルトン不安評価スケール),心配 (ペンシルバニア州不安アンケート),機能障害 (終身機能および障害インストラム,SF-36) が含まれていました.
主要な成果:
- 主要分析では,エシタロプラームの累積応答率 (69%) がプラセボ (51%) (P = .03) と比べて有意に高いことが示されました.
- エシタロプラム治療は,プラセボと比較して,不安症状と役割機能の大きな改善をもたらしました (CGI-IのP <0.001).
- エシタロプラムの副作用には,疲労/眠気 (41.1%),睡眠障害 (14.1%),尿路症状 (9.4%) が含まれていた.
結論:
- エスキタロプラムは,プラセボと比較して12週間にわたってGADを有する高齢者の累積応答率が高いことを示しました.
- 治療意図分析では,回答率の統計的に有意な差は示されなかった.
- この集団におけるエシタロプラムの長期的な有効性および安全性プロフィールを確認するために,さらなる研究が必要である.
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