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Updated: May 2, 2026

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
11:25

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins

Published on: October 4, 2017

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異なる哺乳類のOSTイソフォームによるポリペプチドのコトランスレーションおよびポストトランスレーションによるN-グリコシル化

Catalina Ruiz-Canada1, Daniel J Kelleher, Reid Gilmore

  • 1Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School, Worcester, MA 01605, USA.

Cell
|January 27, 2009
PubMed
まとめ

哺乳類の細胞は,STT3AとSTT3Bという2つのオリゴサカリルトランスフェラーゼ (OST) の同型を用いており,それらは順次一緒に作用する. STT3Aは初期コトランスレーション性グリコシル化を処理し,STT3Bはコトランスレーション性およびポストトランスレーション性N-グリコシル化の両方を媒介する.

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