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Updated: Jun 26, 2026

Uracil-DNA Glycosylase Assay by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry Analysis
12:19

Uracil-DNA Glycosylase Assay by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry Analysis

Published on: April 22, 2022

ウラシルDNAグリコシラーゼの競争抑制は,トリホスファートがDNAポリメラーゼの基質である改変された核酸によって行われます

Haidong Huang1, James T Stivers, Marc M Greenberg

  • 1Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.

Journal of the American Chemical Society
|January 29, 2009
PubMed
まとめ

新しいDNA修復阻害剤である1'-シアノ-2'-デオキシウリジン (CNdU) は,ポリメラーゼによってDNAに組み込まれることができます. これにより,塩基切除修復をターゲットにすることで,ウイルスおよび癌細胞に対する治療効果を拡大することができます.

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Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity14:27

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity

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