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Updated: Jun 26, 2026

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
08:11

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

Published on: November 11, 2022

経膜ポテンシャルに対するカリウムチャネル電圧センサーの初期応答

Werner Treptow1, Mounir Tarek, Michael L Klein

  • 1Center for Molecular Modeling and Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Journal of the American Chemical Society
|January 30, 2009
PubMed
まとめ

Kv1.2 カリウムチャネル電圧センサー (VS) は,ハイパーポラライズされた電圧を適用すると,安定した中間状態に急速に移行します. これは,S2,S3,S4からの電荷の動きが,脂質の相互作用によって安定することを意味します.

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Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors10:59

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Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Resting Membrane Potential01:24

Resting Membrane Potential

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Resting Membrane Potential01:24

Resting Membrane Potential

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The Resting Membrane Potential

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Generation of Action Potential in Skeletal Muscles

Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
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