関連する実験動画
断食中の血糖と脳卒中と心筋梗塞のリスク
Joohon Sung1, Yun-Mi Song, Shah Ebrahim
1Department of Epidemiology, the Graduate School of Public Health, and Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Circulation
|February 4, 2009
まとめ
高血糖 (FBG) の上昇は,糖尿病レベル以下でも,不全性脳卒中のリスクを高めます. 高FBGは心筋梗塞と出血性脳卒中のリスクも高めますが,以前考えられていたよりも著しく低下しています.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- 公衆衛生は公衆衛生である.
背景:
- 糖尿病は,動脈硬化性心血管疾患の既知の危険因子です.
- 糖尿病の値を下回る血糖値に関連した心血管疾患のリスクは十分に理解されていません.
研究 の 目的:
- 韓国の男性の大規模なコホートにおいて,空腹血糖 (FBG) レベルと心血管疾患 (CVD) リスクとの関連性を調査する.
- 現在の糖尿病の値を下回るFBGレベルがCVDイベント,特に脳卒中および心筋梗塞のリスクを伴うかどうかを判断する.
主な方法:
- 652,901人の韓国人男性 (30-64歳) のコホートは,ベースラインのFBGレベルに基づいて8つのグループに分類されました.
- 参加者は,脳卒中や心筋梗塞を含む心血管疾患の発生について,1992年から2001年まで追跡された.
- 年齢,社会経済的地位,行動,その他のCVDリスク要因に調整された統計分析.
主要な成果:
- FBGと心筋梗塞,不全性脳卒中,脳内出血性脳卒中との間の線形関連性は,年齢調整した分析で観察されました.
- 完全調整後,心筋梗塞と脳内出血性脳卒中との関連は軽減され,最高FBGレベル (≥7.5 mmol/L) でのみリスクが増加しました.
- FBGと不全性脳卒中との関連は,完全な調整後も持続し,FBGレベル5.6mmol/Lからリスクの線形増加を示した.
結論:
- 高FBGと心血管疾患のリスクとの関連性は,不全性脳卒中,脳内出血性脳卒中,心筋梗塞の間で異なります.
- 他の危険因子とは無関係に,不良の断食グルコース基準 (≥5.6 mmol/L) 以下のFBGレベルでは,不良性脳卒中のリスクの線形増加が観察されました.
- 糖尿病の現在の診断基準は,韓国人の男性に心筋梗塞と脳内出血性脳卒中のリスクを効果的に特定します.
関連する概念動画
Diabetes: Symptoms, Diagnosis, and Complications
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Hypoglycemia
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...