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Updated: May 5, 2026

Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction
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Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

Published on: August 9, 2011

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レトロウイルスカプシド集合体の欠けているリンクの可視化

Giovanni Cardone1, John G Purdy, Naiqian Cheng

  • 1Laboratory of Structural Biology, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Nature
|February 6, 2009
PubMed
まとめ

研究者は,冷凍電子顕微鏡を用いて,Rousのサルコマウイルスカプシドを観察し,フルレンの推測を確認しました. この研究は,カプシドタンパク質のペンタマーとヘクサマーが,レトロウイルス感染性にとって決定的な,イコサヘドール構造に組み合わされる方法を明らかにしています.

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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