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関連する概念動画

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Transgenic Organisms00:53

Transgenic Organisms

Overview
Transgenic Organisms00:53

Transgenic Organisms

Overview
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

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関連する実験動画

Updated: Jun 25, 2026

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

コメント on "発達強化剤におけるヒト特有の機能増強"

Laurent Duret1, Nicolas Galtier

  • 1Université de Lyon, Université Lyon 1, CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France. duret@biomserv.univ-lyon1.fr

Science (New York, N.Y.)
|February 7, 2009
PubMed
まとめ

人間特異的な配列HACNS1は中立の進化を示し,ポジティブな選択ではない. その機能的変化は,適応ではなく,バイアス的な遺伝子変換の結果である可能性が高い.

科学分野:

  • 進化生物学の進化生物学について
  • ヒューマン・ジェネティクス ヒューマン・ジェネティックス
  • 分子進化は分子進化である.

背景:

  • 保存されたノンコーディングシーケンスHACNS1は,以前,ヒトの適応を促すポジティブセレクション下にあると提案されていた.
  • この仮説は,HACNS1.1における観察された置換パターンに基づいていた.

さらに関連する動画

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

関連する実験動画

Last Updated: Jun 25, 2026

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain
09:59

AAV Deployment of Enhancer-Based Expression Constructs In Vivo in Mouse Brain

Published on: March 31, 2022

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018