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関連する概念動画

The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action potential...
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular cargos...
Actin and Myosin in Muscle Contraction01:16

Actin and Myosin in Muscle Contraction

Actin and myosin are contractile proteins that form the sarcomere found in skeletal muscle tissues for regulating muscle contraction. Actin, a globular contractile protein, interacts with myosin for muscle contraction. The skeletal tissue appears striped or striated under a microscope due to the repeated arrangement of contractile proteins actin and myosin along the length of myofibrils. Dark A bands and light I bands repeat along myofibrils, and the alignment of myofibrils in the cell causes...

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関連する実験動画

Updated: Jun 25, 2026

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

ダイネインが動き出す.

Anne Houdusse1, Andrew P Carter

  • 1Structural Motility Team, Institut Curie, Centre de Recherche, Paris, France.

Cell
|February 11, 2009
PubMed
まとめ

ダイネインのモータータンパク質は,化学エネルギーを運動のための機械力に変換します. この研究は,ダイネインの構造的配置を明らかにしています.

科学分野:

  • 分子生物学は分子生物学である.
  • 細胞力学 細胞力学
  • バイオケミストリー バイオケミストリー

背景:

  • モータータンパク質は,化学エネルギーを機械的な作業に変換する不可欠な分子マシンです.
  • ダイネインは,細胞内輸送と運動に関与する重要な運動タンパク質です.
  • 運動タンパク質における力発生のメカニズムを理解することは,細胞生物学にとって根本的なものです.

研究 の 目的:

  • ダイネイン運動領域内のサブドメインの構造的配置を解明する.
  • ダイネイン媒介による力発生の機能モデルを提案する.

主な方法:

  • ダイネイン運動領域の構造分析.
  • ATPの水解と力生成を研究する生化学的分析.

主要な成果:

  • ダイネインモータードメインのサブドメインの特定の配置の詳細な説明.
  • これらのサブドメインが力を生み出す上で協調した機能を示すモデルを提案した.

結論:

  • サブドメインの特定の配置は,ダイネインの運動機能にとって非常に重要です.

さらに関連する動画

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
07:18

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019

関連する実験動画

Last Updated: Jun 25, 2026

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers
10:45

Analysis of Actomyosin Dynamics at Local Cellular and Tissue Scales Using Time-lapse Movies of Cultured Drosophila Egg Chambers

Published on: June 3, 2019

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction
06:05

Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction

Published on: April 27, 2011

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
07:18

Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo

Published on: July 9, 2019

  • 提案されたモデルは,ダイネインによる力発生の分子機構の洞察を提供します.