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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

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IFNアルファは,静止している血液形成性幹細胞を in vivo で活性化させます

Marieke A G Essers1, Sandra Offner, William E Blanco-Bose

  • 1Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

Nature
|February 13, 2009
PubMed
まとめ

インターフェロン-アルファ (IFNalpha) は,休眠している血球形成性幹細胞 (HSC) を増殖させるために目覚めさせることができるが,慢性的な曝露は,その機能を損なう. この発見は,がん幹細胞を標的とする新たな戦略の可能性を秘めている.

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