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Updated: Jun 25, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

RNAリガースリボ酵素の地域選択性の構造誘導工学

Jason N Pitt1, Adrian R Ferré-D'Amaré

  • 1Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA.

Journal of the American Chemical Society
|February 18, 2009
PubMed
まとめ

RNA複合体の構造的な違いは,リボ酵素が2'-5'または3'-5'RNA結合を形成するかどうかを決定する. この発見は,RNA世界の起源とRNA合成のためのリボ酵素工学の理解に影響を与えます.

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Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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Ribozymes02:47

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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can be...
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Riboswitches

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