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関連する概念動画

Heterogeneous Catalysis01:22

Heterogeneous Catalysis

Heterogeneous catalysis involves a catalyst in a different phase from the reactants. It is a process where the catalyst and the reactants are in distinct phases, typically solid and gas or liquid.Most heterogeneous catalysts are metals, metal oxides, or acids. The list includes transition metals like iron (Fe), cobalt (Co), nickel (Ni), palladium (Pd), platinum (Pt), chromium (Cr), manganese (Mn), tungsten (W), silver (Ag), and copper (Cu). These metals possess partially vacant d orbitals that...
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...
Catalysis01:27

Catalysis

Catalysis influences the rate of chemical reactions by providing an alternative reaction pathway with lower activation energy. A catalyst speeds up a reaction, but it is not consumed during the process. The fundamental principle of catalysis is the ability of a catalyst to alter the reaction mechanism, often introducing a more efficient pathway than the uncatalyzed process.In a catalyzed reaction, the catalyst participates directly in the reaction mechanism. It interacts with reactants to form...
Catalysis02:50

Catalysis

The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...

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関連する実験動画

Updated: Jun 25, 2026

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

構造的ダイナミクスと機能的多様性を非対称な触媒で結びつける.

Akihiro Nojiri1, Naoya Kumagai, Masakatsu Shibasaki

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|February 24, 2009
PubMed
まとめ

研究者は,タンパク質の柔軟性を模倣して,動的な構造変化を持つ新しい触媒を開発しました. このイノベーションは,非対称な触媒の単一の触媒から2つの異なる反応結果を可能にし,化学合成を進める.

科学分野:

  • カタリシス カタリシス カタリシス
  • 化学生物学 化学生物学とは
  • 有機化学 オーガニック・ケミストリー

背景:

  • タンパク質は,驚くべき構造的柔軟性を発揮し,アロステル調節と翻訳後の修正を通じて多様な機能を可能にします.
  • エナチオセレクティブ触媒は,通常,構成の柔軟性が限られており,特定の機能に限定されます.
  • 生物学的システムと合成システムの間のギャップを埋めるには,適応可能な構造と機能を備えた触媒が必要です.

研究 の 目的:

  • タンパク質の構成の変化にインスパイアされた,ダイナミックな構造的および機能的適応性を備えた触媒を設計する.
  • 非対称な触媒で単一の触媒システムを用いて,複数の異なる反応結果を達成する.
  • 触媒設計における構造的に柔軟なリガンドと希土金属の有用性を探求する.

主な方法:

  • 動的構造的適応のために設計された形状的に柔軟な非対称リガンドを使用した.
  • 変数の調整パターンで知られている稀土金属を使用した.
  • 単一の反応ボスクの中で構造的,機能的変化をダイナミックに起こすことができる触媒システムを開発した.

主要な成果:

  • 触媒のダイナミックな構造変化が示され,リガンドと金属の協調によって影響を受けています.

さらに関連する動画

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

関連する実験動画

Last Updated: Jun 25, 2026

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics
10:52

Multiscale Sampling of a Heterogeneous Water/Metal Catalyst Interface using Density Functional Theory and Force-Field Molecular Dynamics

Published on: April 12, 2019

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
12:08

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes

Published on: June 24, 2022

  • エンジニアリングされた触媒を用いた非対称な触媒で2つの異なる反応結果を達成しました.
  • 構造的再配置に基づいてその機能を調節する触媒の能力を示した.

    • 結論:

    • この研究は,ダイナミックな構造的柔軟性を組み込むことにより,触媒設計に対する新しいアプローチを提示しています.
    • この研究は,合成触媒システムにおけるタンパク質の機能的適応性を模倣しています.
    • 開発された触媒は,非対称な触媒で複数の結果を達成するための汎用性のあるプラットフォームを提供し,より効率的な化学合成への道を開きます.