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核因子Bの活性化は,過体重/肥満中年および高齢のヒトにおける酸化ストレスによる血管内皮機能障害に寄与する

Gary L Pierce1, Lisa A Lesniewski, Brooke R Lawson

  • 1Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA. gpierce@colorado.edu

Circulation
|February 25, 2009
PubMed
まとめ

核因子-kappaB (NF-kappaB) の活動は,老化および肥満のヒトにおける血管内皮機能不全に寄与する. 塩酸でNF-kappaBを阻害すると,血管機能が改善され,酸化ストレスが軽減され,この機能障害における重要な役割が示唆されています.

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