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関連する概念動画

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

長いノンコーディングRNAの進化と機能

Chris P Ponting1, Peter L Oliver, Wolf Reik

  • 1MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK. chris.ponting@dpag.ox.ac.uk

Cell
|February 26, 2009
PubMed
まとめ
この要約は機械生成です。

長いノンコーディングRNA (lncRNAs) は,単なる転写ノイズではなく,重要な調節分子です. このレビューでは,それらの進化,遺伝子調節における役割,および病気との関連について考察します.

さらに関連する動画

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

関連する実験動画

Last Updated: Jun 25, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • ゲノミクスゲノミクスとは

背景:

  • RNA分子は,タンパク質合成を超えて多様な機能を果たします.
  • ユカリオットゲノムは,多くの非タンパク質コーディングRNA種を生成する.
  • 長いノンコーディングRNA (lncRNAs) は,まだ十分に研究されていない重要なトランスクリプトのクラスです.

研究 の 目的:

  • lncRNAsの進化的起源をレビューする.
  • 遺伝子発現におけるlncRNAsの調節的な役割を解明する.
  • 人体疾患における lncRNAs の関与を調査する.

主な方法:

  • lncRNAs.に関する既存の研究の文献レビューと合成.
  • lncRNA遺伝子の進化軌道を分析する.
  • 転写および表遺伝的調節におけるlncRNA機能に関するデータの統合.

主要な成果:

  • lncRNAは多様な進化パターンを表しています.
  • lncRNAは,複雑な遺伝子調節ネットワークに不可欠です.
  • lncRNAsの調節不良は,様々な病理学的状態に関与しています.

結論:

  • lncRNAは機能的に重要なもので,単なる転写副産物ではありません.
  • lncRNAの進化を理解することは,その規制メカニズムについての洞察を提供します.
  • lncRNAsは,疾患の診断と治療のための有望なターゲットです.