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Updated: Jun 25, 2026

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)
09:26

Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)

Published on: July 10, 2019

RNAの分解の多くの経路は,

Jonathan Houseley1, David Tollervey

  • 1Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR, UK.

Cell
|February 26, 2009
PubMed
まとめ

細胞はRNAを積極的に分解し,保存するよりも多くを転写する. 細胞機能に不可欠なこの制御されたRNA分解は,欠陥のある分子を標的とし,特定のRNA標的を認識するために不可欠です.

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Single-step Purification of Macromolecular Complexes Using RNA Attached to Biotin and a Photo-cleavable Linker08:12

Single-step Purification of Macromolecular Complexes Using RNA Attached to Biotin and a Photo-cleavable Linker

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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