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Updated: Dec 29, 2025

Live-Cell Förster Resonance Energy Transfer Imaging of Metabolically Regulated Akt Activation Dynamics in HepG2 Cells
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Live-Cell Förster Resonance Energy Transfer Imaging of Metabolically Regulated Akt Activation Dynamics in HepG2 Cells

Published on: May 23, 2025

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PP2Aの調節サブユニットは,AKT-1のリン酸化を調節することによって,C. elegansのインスリン/IGF-1シグナリングを調節する

Srivatsan Padmanabhan1, Arnab Mukhopadhyay, Sri Devi Narasimhan

  • 1University of Massachusetts Medical School, Worcester, 01605, USA.

Cell
|March 3, 2009
PubMed
まとめ

この研究では,B56のサブユニットであるPPTR-1を,虫のインスリン/IGF-1シグナル伝達 (IIS) 経路の重要なレギュラーとして特定しています. PPTR-1はAKTを脱酸化し,寿命と代謝に影響を及ぼし,哺乳類における役割は保存されています.

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