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Updated: Jun 25, 2026

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method
05:51

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method

Published on: July 19, 2019

イソメリゼーション中のプロリン二ペプチドの両側でピラミダイゼーションを誘導する分子内および分子間相互作用:明示的な水中のab initio QM/MM分子動態シミュレーション研究

Yasushige Yonezawa1, Kazuto Nakata, Kota Sakakura

  • 1Institute for Protein Research, Osaka University, 3-2 Yamada-oka, Suita, Osaka 565-0871, Japan. yasuyon33@protein.osaka-u.ac.jp

Journal of the American Chemical Society
|March 10, 2009
PubMed
まとめ

プロリン残留前におけるペプチド結合のシス・トランス・イソメリゼーションは,タンパク質の折り畳みに極めて重要です. この研究は,ピラミッド型の窒素構造と結合拡張を含む新しい移行状態のメカニズムを明らかにし,イソメリゼーションプロセスを明確にします.

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