腎臓細胞癌は,腎臓細胞がんに
Brian I Rini1, Steven C Campbell, Bernard Escudier
1Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
Lancet (London, England)
|March 10, 2009
まとめ
腎臓細胞癌の治療の進歩には,侵襲的外科手術と標的治療が含まれています. 免疫療法による免疫療法です.
科学分野:
- 腫瘍学 腫瘍学
- ネフロロジーは腎臓科です.
背景:
- 腎臓細胞癌 (RCC) の管理は,外科的および全身的革新とともに進化してきました.
- 現在の標準には,小型の腫瘍に対する部分腎切除と,大型の腫瘍に対する急性腎切除が含まれており,腎機能の保存を優先しています.
- 細胞還元性腎切除術は,全身治療の前に転移性RCCの重要な戦略です.
研究 の 目的:
- 腎臓細胞がんの治療における最近の進歩をレビューする.
- 外科療法と全身療法が果たす役割の進化を強調する.
- 標的療法と免疫療法の影響を議論する.
主な方法:
- 腎臓細胞癌の治療戦略に関する現在の文献のレビュー.
- ネフレクトミーを含む外科的アプローチの分析. 腎臓切除の種類.
- 免疫療法や標的薬などの全身療法の評価.
主要な成果:
- 最小侵襲的外科手術と腎臓保存技術は,局所的なRCCの標準です.
- 細胞還元性腎切除は,転移性疾患の管理において依然として重要である.
- 標的型療法 (VEGFおよびmTOR阻害剤) は,転移性RCCにおいて有意な有効性を示しているが,免疫療法の役割はより選択的である.
結論:
- 腎臓の保存に重点を置いた外科技術が改善され続けている.
- 標的治療は,転移性腎臓細胞癌の主要な進歩を表しています.
- 免疫療法の使用と組み合わせ戦略を最適化するためにさらなる研究が必要です.
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