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Updated: Jun 25, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

複製交換分子ダイナミクスシミュレーションによって予測されたアミロイド前駆体タンパク質二重体のトランス膜構造

Naoyuki Miyashita1, John E Straub, D Thirumalai

  • 1RIKEN Computational Science Research Program, Molecular Scale Team, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Journal of the American Chemical Society
|March 12, 2009
PubMed
まとめ

アミロイド前駆タンパク質 (APP) の変異は,アルツハイマー病の病原性を変化させる可能性があります. この研究は,特定のAPP変異がタンパク質の構造をどのように変化させ,有毒なアベタペプチド分泌を潜在的に減少させるかを明らかにしています.

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